HyDES

Instant Dissolution, Rapid Absorption

Oral drug bioavailability faces challenges due to poor solubility and permeability in many pharmaceutical compounds.

Our HyDES formulation technology specifically targets and enhances solubility and bioavailability for APIs, particularly those with high melting points and a weakly basic nature, thereby advancing oral drug delivery and therapeutic effectiveness.

 

The HyDES platform creates a hydrophilic eutectic solvent capable of incorporating up to 30% drug load, easily encapsulated in standard gelatin capsules. In humans, this formulation induces a supersaturated state, enhancing drug absorption. Demonstrated in a case study with Atazanavir, a notoriously insoluble drug, HyDES significantly raised bioavailability — over 700% compared to crystalline API and by more than 75% against an amorphous solid dispersion.

Atazanavir in vivo Case Study

Benefits of HyDES platform

 

Up to 25% drug loading

 

Significant bioavailability enhancement

 

 

Physically stable

 

One-step manufacturing 

 

What drug molecule is the eutectic platform suitable for?

Perfect formulation approach for API's that are:

 

(Weakly) basic                                                                                High melting point

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