Our Technology

 

Poor water solubility of active pharmaceutical ingredients is a major hurdle in pharmaceutical industry development. It contributes to an expensive, time-consuming and often unsuccessful development process. Our eutectic formulation platforms can be successfully applied to a broad range of APIs, are cost-effective and reduce time to clinical phases.

 

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Bioavailability enhancement techniques

 

TechniqueParticle size reductionSolid Form ManipulationSolubilization

Examples

  • Micronization
  • Nanosuspensions
  • Amorphous Solid Dispersions (ASD)
  • Cocrystals
  • Lipids, surfactants and cosolvents
  • Cyclodextrins
  • Eutectic Technology Platforms
Benefits
  • Enhanced bioavailability for early clinical phases
  • Recognized and accepted formulation approach
  • Enhanced bioavailability
  • Recognized and accepted formulation approach
  • Chemically stable
  • Enhanced bioavailability
  • Recognized and accepted formulation approach
  • Physically stable
  • Simple manufacturing
  • Enhanced bioavailability
  • Physically stable
  • Simple manufacturing
  • High drug loading
Challenges
  • Physically unstable
  • Complex and expensive manufacturing
  • Physically unstable
  • Complex and expensive manufacturing
  • Low drug loading (often <5%)
  • Additional screening required
  • Less well-known formulation approach

Our formulation technologies

Eutectic Formulation

Turn an API into a solvent

 

  • High drug load
  • Significant Bioavailability enhancement
  • Physically stable
  • Simple manufacturing
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LiDES

Same lipid functionality with significantly higher drug load

 

  • High drug load lipids
  • Significant Bioavailability enhancement
  • Physically stable
  • Simple manufacturing
Learn more

Eutectic Enteric

Deliver the formulation straight to the absorptive environment

 

  • Optimal intestinal release
  • Significant Bioavailability enhancement
  • Physically stable
  • Simple manufacturing
Learn more

Other administrative routes

Formulations for other administration routes and purposes

 

  • Enhanced drug loading
  • Significant Bioavailability enhancement
  • Excellent toxicity profile
  • Simple manufacturing
Learn more

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