Deep eutectic solvents are multicomponent systems with a melting point much lower than each of the individual components. This melting point depression effect is usually driven by hydrogen bonding interactions between the components. A naturally occurring example of a deep eutectic solvent is honey. Honey contains about 85% of solid components that melt above 100 °C in pure form (glucose, fructose, sucrose and maltose), but when these sugars are combined in the right ratio, in presence of around 15% of water, the resulting mixture liquefies at room temperature. We are harnessing this very principle for the delivery of poorly water-soluble drugs.
Starting from a library of over hundred GRAS excipients with hydrogen bonding potential (like amino acids, sugars or sugar alcohols), we tailor-make new solvents for the most physicochemically diverse small-molecule APIs. The flexibility of our technology combined with the efficiency of our screening techniques allows us to design formulations with far higher solvent capacity for poorly soluble APIs than traditional solubilization techniques. This opens new possibilities to enhance the oral bioavailability of poorly water-soluble drugs and unlocks a whole host of product development opportunities for diverse applications including intravenous, pediatric, veterinary and nutraceutical formulations.
- Powerful solubility enhancement
- Broad applicability
- High API loadings
- Well-tolerated excipients
- Ease of manufacture