Unlocking the softgel formulation option for FEXO

FEXO is a widely used over-the-counter therapeutic to treat hay fever, seasonal allergies and urticaria. It is commercially available in a variety of presentations, including tablets, powder-filled capsules and suspensions. However, there is no FEXO softgel formulation on the market, in spite of a strong preference for this type of dosage form by the consumer healthcare market. This is related to the low solubility of FEXO in liquid excipients, combined with a high dose requirement (180 mg). Using our deep eutectic solvent technology, we have developed a physically and chemically stable liquid fill, containing 350 mg/ml of FEXO. This enabled us to fill the 180 mg dose in a single size 10 softgel - a problem that traditional solubilisation technologies have been unable to solve.

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