In a feasibility study, we first focus on designing a deep eutectic solvent in which the API is highly soluble and chemically stable. This involves the screening of a selection of constituents at multiple ratios. When systems that meet these criteria have been identified, we optimise for dissolution performance by evaluating the utility of disintegrants, surfactants and polymeric precipitation inhibitors.
The key deliverable of a feasibility study is a report with clear conclusions and recommendations for follow-up work. Small samples of prototype formulations to support further testing by the sponsor (for exampe in vitro dissolution or in vivo studies to compare performance against reference formulations) can also be provided.