We Solve Oral Bioavailability Challenges in Small Molecules and Protein Degraders.

NanoGlass™ Technology

What We Do

In two weeks, our feasibility studies provide early in vivo proof of improved oral bioavailability.
NanoGlass™ platforms generate and stabilize amorphous nanoparticles of the API in situ, improving solubility, dissolution, and absorption while addressing stability and manufacturability for challenging APIs.
This approach has been applied across protein degraders, small molecules, peptides, and emerging modalities.

GlassE™

Instant Release Glass

A polymer free solid formulation with instant release to generate amorphous nanoparticles in the stomach. With high drug loading, chemical stability and rapid API release.

GlassA™

Controlled Release Glass

A solid formulation enabling high drug loading, controlled API release, and improved chemical stability, giving a tablet final dosage form.

HyGlass™

Hydrophilic Liquid

High drug load hydrophilic liquid formulation with simplified manufacturing and a capsule final dosage form.

LiGlass™

Lipophilic Liquid

The same high oral bioavailability as traditional lipid formulations with a 10x higher drug loading with a capsule final dosage form.

Technology Users

Where We add value

Small Molecules

Solubility is maximally enhanced by the formation of amorphous nanoparticles using NanoGlass™ technologies. This improves bioavailability while reducing variability, pill burden, and side effects. The result is a robust, patient-friendly dosage form designed to advance smoothly through development.

Protein Degraders

These large, complex molecules present dual challenges of poor solubility and permeability. NanoGlass™ platforms address both by enhancing solubility and using permeation enhancers, enabling oral delivery of even the most difficult-to-formulate degraders.

Peptides

Oral peptide delivery requires overcoming degradation and absorption barriers. NanoGlass™ platforms protect peptides from enzymatic breakdown while enhancing permeability, supporting the development of effective and convenient oral dosage forms.

How we Help

Understand Your Needs

We start by listening carefully to understand your molecule, goals, and timeline. Together, we define a clear project scope tailored precisely to your development objectives.

Feasibility Study

Using minimal API and rapid timelines, we quickly determine your molecule’s stability profile, solubility challenges, and optimal formulation strategy.

Formulation Optimisation

We rapidly prototype and optimize candidate formulations, leveraging our NanoGlass™ platforms to achieve targeted drug load, dissolution, and bioavailability.

Clinical Manufacturing

We develop robust, scalable formulations for preclinical studies and ensure a seamless transition of the optimal formulation to clinical-scale manufacturing.